Those things [Nobel Prizes] should come with warning labels: "CAUTION! DOES NOT GRANT SUPERHUMAN MENTAL POWERS!"As I've always said, it's good to have an "open mind" in science. That's how nearly all the major advances come about, from scientists with open minds and a willingness to work very hard on their ideas using rigorous scientific method. But you really do have to make sure your mind is not so open that your brains fall out. You do have to keep in mind what is and is not likely--or even possible.
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A Photon in the Darkness has an excellent piece on the difference between "thinking outside the box" and "going around the bend" (although I would have phrased it as "going off the deep end"). I particularly like the part where he points out that even Nobel Laureates are not immune to going off the deep end when they wander outside of their field of expertise, with this warning: